Thermo Fisher Scientific ESRRB Recombinant Rabbit Monoclonal Antibody (9H8L3)
Human ESRRB 단백질을 인식하는 재조합 토끼 단클론 항체로, ICC/IF에 적합합니다. 높은 특이성과 민감도를 제공하며 로트 간 일관성이 우수합니다. 단백질 A로 정제된 액상 형태이며, 단기 4°C 보관 및 장기 -20°C 보관을 권장합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9H8L3 |
| Immunogen | Peptide corresponding to human ESRRB (aa73–aa86) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2762388 |
Product Specific Information
This antibody is predicted to react with Monkey, Horse, Pig, and Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
ESRRB (steroid hormone receptor ERR2) plays a role in maintaining self-renewal and pluripotency of embryonic and trophoblast stem cells through signaling pathways such as FGF and Wnt. Upon activation of FGF signaling, ESRRB interacts with KDM1A by binding to enhancer sites of ELF5 and EOMES, activating their transcription and promoting trophoblast stem cell self-renewal.
ESRRB also regulates expression of rod-specific genes and is essential for survival of these cells. Mutations in ESRRB can cause autosomal recessive deafness type 35 (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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