Thermo Fisher Scientific ESRRB Recombinant Rabbit Monoclonal Antibody (9H8L3)

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Horse, Pig, and Cat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

ESRRB (steroid hormone receptor ERR2) plays a role in maintaining self-renewal and pluripotency of embryonic and trophoblast stem cells through signaling pathways such as FGF and Wnt. Upon activation of FGF signaling, ESRRB interacts with KDM1A by binding to enhancer sites of ELF5 and EOMES, activating their transcription and promoting trophoblast stem cell self-renewal.

ESRRB also regulates expression of rod-specific genes and is essential for survival of these cells. Mutations in ESRRB can cause autosomal recessive deafness type 35 (DFNB35).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.