Thermo Fisher Scientific CRM1 Recombinant Rabbit Monoclonal Antibody (8H4L7)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Product Specifications

Product Specific Information

• This antibody is predicted to react with Monkey, Bovine, and Pig.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems.
• These systems clone specific antibody DNA sequences from immunoreactive rabbits, and individual clones are screened for optimal performance.
• Advantages include:
  • High specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulation
  • Broader immunoreactivity due to the rabbit immune repertoire

Target Information

Exportin-1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs.
In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP).
Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins.
Upon transit of a nuclear complex into the cytoplasm, disassembly and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor.
The directionality of nuclear export is conferred by the asymmetric distribution of Ran-GTP and Ran-GDP between cytoplasm and nucleus.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.