Thermo Fisher Scientific Phospho-Tyrosine Hydroxylase (Ser40) Recombinant Rabbit Monoclonal Antibody (5H9L20)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with Human, Monkey, Cat, and Mouse.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters—dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by TH interaction with tetrahydrobiopterin (BH4), which binds to the catalytic domain to activate the enzyme.

Human TH has four mRNA splice variants (hTH1–hTH4) differing in their N-terminal regulatory domains but sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.

TH is associated with several neuropathogenic and cardiovascular diseases, including:

• Parkinson’s disease
• Schizophrenia
• Segawa syndrome
• Dystonia

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.