Thermo Fisher Scientific FE65 Polyclonal Antibody
FE65 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트에 반응하며 Western blot에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 알츠하이머 병 관련 연구에 활용 가능.
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Thermo Fisher Scientific FE65 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues of human FE65 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 33 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987095 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with FE65L1 or FE65L2.
Target Information
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus and interacts with the Alzheimer’s disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1, and the low-density lipoprotein receptor-related protein. APP acts as a cytosolic anchoring site that can prevent nuclear translocation of the encoded protein. This protein may play an important role in the pathogenesis of Alzheimer’s disease and is thought to regulate transcription. It has been observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene, though some full-length sequences remain unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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