Thermo Fisher Scientific Perforin Polyclonal Antibody
Mouse Perforin을 인식하는 Rabbit Polyclonal Antibody로 Western Blot에 최적화됨. 합성 펩타이드 면역원 사용. 액상 형태, 113 µg/mL 농도, -20°C 보관. 세포독성 림프구의 퍼포린 연구에 적합한 연구용 항체.
- 카탈로그번호
- PA517431
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding leucine 349 of mouse perforin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 113 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10980106 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Perforin is one of the major cytolytic proteins of cytolytic granules. It acts as a cytolytic mediator stored in and released by cytoplasmic granules. Perforin plays a key role in immune defense against tumors and viral infections mediated by cytotoxic lymphocytes.
This protein consists of 555 amino acids with a 21 amino acid signal peptide and has a molecular weight of 70–75 kDa.
Perforin forms transmembrane channels similar to complement component C9, showing structural homology. It is expressed only in killer cell lines, not in helper T lymphocytes or other tumor cells.
Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare, lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-17431_Perforin_P10820-1_Rabbit.svg, PA5-17431_Perforin_P10820-1_Rabbit_PDP.jpeg)
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