Thermo Fisher Scientific Phospho-beta Catenin (Ser715) Polyclonal Antibody
Human, Mouse, Rat 시료에 반응하는 beta Catenin Ser715 인산화 특이 폴리클로날 항체. Western blot 및 IHC(P) 검증 완료. 액상 형태, 1 mg/mL 농도, PBS/glycerol buffer에 보존. 연구용으로 종양 및 세포 접착 관련 신호 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide sequence derived from Human beta Catenin around phosphorylation site of serine 715 (D-P-S(p)-Y-R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2692101 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin to anchor the E-cadherin complex to the actin cytoskeleton. Beta-catenin also binds to complexes containing adenomatous polyposis coli protein and microtubules, participating in signaling pathways such as tyrosine kinases, phosphatases, and Wnt/Wingless.
Beta-catenin expression is found in several hair follicle cell types and epithelial cells. It plays a pathological role in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other solid tumors. In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, stimulating genes like cyclin D and c-myc, which promote cell proliferation and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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