Thermo Fisher Scientific Phospho-JAK2/JAK3 (Tyr966, Tyr939) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human JAK2/JAK3 around the phosphorylation site of Tyr966/939. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:JAK2/JAK3,uniProtId:O60674-1,ncbiNodeId:9606,antigenRange:966,antigenLength:1132,antigenImageFileName:PA5-67508_JAK2JAK3_O60674-1_Rabbit.svg,antigenImageFileNamePDP:PA5-67508_JAK2JAK3_O60674-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:JAK2/JAK3,uniProtId:P52333-1,ncbiNodeId:9606,antigenRange:939,antigenLength:1124,antigenImageFileName:PA5-67508_JAK2JAK3_P52333-1_Rabbit.svg,antigenImageFileNamePDP:PA5-67508_JAK2JAK3_P52333-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2692002

Product Specific Information

Predicted to react with Rat samples.

Target Information

Janus Activating Kinase 2 and 3 (JAK2/JAK3) is one of a number of related tyrosine kinases involved in cytoplasmic signal transduction. In response to a varitety of cytokine or related factors (e.g., interferon, interleukins), JAKs are activated via phosphorylation at 2 adjacent tyrosine residues. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. However, active JAK1 may be required for complex responses. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.