Thermo Fisher Scientific PPAR gamma-2 Polyclonal Antibody, Alexa Fluor 555

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-824 detects peroxisome proliferator activated receptor (PPAR) gamma-2 from human and mouse tissues.
This antibody does not detect PPAR alpha or PPAR delta.
The immunogen is a synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2.
This sequence is not conserved in PPAR gamma-1.

Target Information

Peroxisome proliferators are non-genotoxic carcinogens that act through nuclear hormone receptors known as peroxisome proliferator activated receptors (PPARs).
PPARs are ligand-dependent intracellular proteins that regulate transcription by binding to specific DNA sequences upon activation.
They are activated by compounds such as clofibric acid, nafenopin, WY-14,643, and certain fatty acids.
PPARs induce transcription of acyl-CoA oxidase and cytochrome P450 A6 through specific response elements.
PPAR alpha is activated by free fatty acids like linoleic, arachidonic, and oleic acids, leading to reduced blood triglyceride levels.
PPAR alpha is mainly expressed in skeletal muscle, heart, liver, and kidney, and regulates genes involved in fatty acid beta-oxidation.
Activation of rat liver PPAR alpha can suppress hepatocyte apoptosis.
PPAR gamma-2, similar to other nuclear hormone receptors, forms a transcriptionally active complex with retinoid X receptor (RXR) alpha.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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