Thermo Fisher Scientific LGR5 Monoclonal Antibody (UMAB212), UltraMAB
LGR5 단백질을 인식하는 고특이성 마우스 단클론 항체로, Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합. Human 시료 반응성, Lyophilized 형태로 제공되며, 연구용으로 사용 가능. 고순도 Affinity chromatography 정제.
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Thermo Fisher Scientific LGR5 Monoclonal Antibody (UMAB212), UltraMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| ChIP assay (ChIP) | Assay-dependent |
| Peptide Array (Array) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB212 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–543 of human LGR5 produced in HEK293 cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
G protein-coupled receptor GPR49 (LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries, as well as from germ cell, uterus, and brain libraries.
GPCRs are one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices, existing in active and inactive forms. Ligand binding induces conformational changes leading to G-protein-mediated signaling and downstream effects.
Negative regulation of GPCRs plays a crucial role in cellular physiology and pharmacological research. GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) highlight the therapeutic importance of this receptor family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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