Thermo Fisher Scientific LGR5 Monoclonal Antibody (UMAB212), UltraMAB
LGR5 단백질을 인식하는 Mouse monoclonal antibody (Clone UMAB212). Human 및 Mouse 시료에 반응. Flow Cytometry 등 다양한 응용에 적합. Affinity chromatography로 정제된 액상 항체로, PBS 내 0.02% sodium azide 포함. 연구용으로만 사용 가능.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 50 tests
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB212 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–543 of human LGR5 produced in HEK293 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
G protein-coupled receptor GPR49 is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries and from human germ cell, uterus, and brain libraries.
G-protein Coupled Receptors (GPCRs) are one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices and existing in both active and inactive forms.
Activation of GPCRs triggers signaling via G-proteins and downstream effectors, while negative regulation (“turn-off” activity) influences physiological responses and drives pharmacological research for new drug candidates.
Notable GPCR-targeted drugs include Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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