Thermo Fisher Scientific LGR5 Monoclonal Antibody (UMAB211), UltraMAB
LGR5 단백질을 인식하는 Mouse IgG2a 형 단일클론 항체로 다양한 응용(WB, IHC, ICC, Flow 등)에 사용 가능. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도 유지. 인간 유래 LGR5 단백질(aa 22-543)을 면역원으로 사용. 연구용으로만 사용.
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Thermo Fisher Scientific LGR5 Monoclonal Antibody (UMAB211), UltraMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| ChIP assay (ChIP) | Assay-Dependent |
| Peptide Array (Array) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB211 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 22–543 of human LGR5 produced in HEK293 cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
G protein-coupled receptor GPR49 (LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries, as well as germ cell, uterus, and brain libraries.
GPCRs form one of the largest families of signaling molecules with over a thousand members predicted. They share a structural motif of seven membrane-spanning helices and exist in active and inactive forms. Ligand binding induces conformational changes leading to G-protein signaling and downstream effects.
Negative regulation of GPCRs plays an important role in cellular physiology and pharmacological research. GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) demonstrate the therapeutic potential of this receptor family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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