Thermo Fisher Scientific Phospho-VE-cadherin (Tyr685) Polyclonal Antibody
Phospho-VE-cadherin (Tyr685) 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot에 최적화되어 있으며, 세포 간 결합 및 내피세포 생물학 연구에 유용합니다. 항원 친화 정제 방식으로 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-VE-Cadherin (Tyr-685) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding tyrosine 685 in human VE-cadherin. This sequence has significant homology to the conserved site in rat and mouse VE-cadherin, but is not conserved in other cadherins. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942889 |
Product Specific Information
This antibody was cross-adsorbed to an unrelated phospho-tyrosine peptide and unphosphorylated VE-cadherin (Tyr-685) peptide before affinity purification using phospho-VE-cadherin (Tyr-685) peptide.
The purified antibody detects a 140 kDa band corresponding to VE-cadherin in western blots of human endothelial cells treated with pervanadate, and this band is not detected in untreated cells or after alkaline phosphatase treatment.
Target Information
VE-cadherin is a member of the cadherin superfamily located in a six-cadherin cluster on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer.
VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail.
Functioning as a classic cadherin by enabling homophilic adhesion, VE-cadherin plays an important role in endothelial cell biology by controlling cohesion and organization of intercellular junctions.
An alternative splice variant has been described, but the full-length sequence of VE-cadherin has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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