Thermo Fisher Scientific Phospho-VE-cadherin (Tyr685) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody was cross-adsorbed to an unrelated phospho-tyrosine peptide and unphosphorylated VE-cadherin (Tyr-685) peptide before affinity purification using phospho-VE-cadherin (Tyr-685) peptide.
The purified antibody detects a 140 kDa band corresponding to VE-cadherin in western blots of human endothelial cells treated with pervanadate, and this band is not detected in untreated cells or after alkaline phosphatase treatment.

Target Information

VE-cadherin is a member of the cadherin superfamily located in a six-cadherin cluster on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer.
VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail.
Functioning as a classic cadherin by enabling homophilic adhesion, VE-cadherin plays an important role in endothelial cell biology by controlling cohesion and organization of intercellular junctions.
An alternative splice variant has been described, but the full-length sequence of VE-cadherin has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.