Thermo Fisher Scientific CD276 Monoclonal Antibody (4E12)

Applications

• Western Blot (WB): 1–5 µg/mL
• ELISA: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ITPQRSPTGA VEVQVPEDPV VALVGTDATL RCSFSPEPGF SLAQLNLIWQ LTDTKQLVHS FTEGRDQGSA YANRTALFPD LLAQGNASLR LQRVRVADEG SFTCFVSIRD FGSAAVSLQV AA

Target Information

CD276, also known as B7-H3, is a member of the B7 family of co-stimulatory molecules.
It is a type I transmembrane protein that:

• Induces proliferation of CD4+ and CD8+ T cells
• Enhances generation of cytotoxic T cells
• Stimulates production of interferon gamma

Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines.
It is widely expressed in peripheral tissues such as heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing.
CD276 shows therapeutic potential in regulating cell-mediated immune responses to cancer, particularly with anti-angiogenic therapy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.