Thermo Fisher Scientific CD276 Monoclonal Antibody (7C10)
CD276(B7-H3) 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, ICC/IF, ELISA에 사용 가능. 인간 시료 반응성, PBS 기반 액상 형태, 보존제 없음. 세포 면역반응 및 암 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7C10 |
| Immunogen | CD276 (AAH62581.1, 28–238 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ALEVQVPEDP VVALVGTDAT LCCSFSPEPG FSLAQLNLIW QLTDTKQLVH SFAEGQDQGS AYANRTALFP DLLAQGNASL RLQRVRVADE GSFTCFVSIR DFGSAAVSLQ VAAPYSKPSM TLEPNKDLRP GDTVTITCSS YQGYPEAEVF WQDGQGVPLT GNVTTSQMAN EQGLFDVHSI LRVVLGANGT YSCLVRNPVL QQDAHSSVTI T
Target Information
CD276 (B7-H3) is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that induces proliferation of CD4+ and CD8+ T cells, enhances cytotoxic T cell generation, and selectively stimulates interferon gamma production.
Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines and is widely expressed in peripheral tissues such as heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing.
CD276 has therapeutic potential for regulating cell-mediated immune responses to cancer, especially in combination with anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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