Thermo Fisher Scientific MKP-1 Polyclonal Antibody
MKP-1(DUSP1) 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Affinity chromatography로 정제되었으며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DUSP1 (Accession P28562), corresponding to amino acid residues T335–C367. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853876 |
Product Specific Information
Antibody detects endogenous levels of total DUSP1/MKP1.
Target Information
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative or heat stress and growth factors. It encodes a protein similar to non-receptor-type protein-tyrosine phosphatases and shows significant sequence similarity to a Tyr/Ser-protein phosphatase from vaccinia virus. The bacterially expressed DUSP1 protein exhibits intrinsic phosphatase activity and specifically inactivates MAP kinase by dephosphorylating both phosphothreonine and phosphotyrosine residues. It also suppresses MAP kinase activation by oncogenic ras in Xenopus oocyte extracts, suggesting its role in cellular stress response and negative regulation of proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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