Thermo Fisher Scientific TRAF1 Polyclonal Antibody
TRAF1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 IHC(Paraffin)에서 검증되었습니다. Affinity chromatography로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TRAF1 (Accession Q13077), corresponding to amino acid residues Q372–T416 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853881 |
Product Specific Information
Antibody detects endogenous levels of total TRAF1.
Target Information
The protein encoded by this gene is a member of the TNF receptor (TNFR)-associated factor (TRAF) protein family. TRAF proteins mediate signal transduction from various TNFR superfamily receptors. TRAF1 forms a heterodimeric complex with TRAF2, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. This complex also interacts with inhibitor-of-apoptosis proteins (IAPs), mediating anti-apoptotic signals from TNF receptors. Expression of this protein can be induced by Epstein-Barr virus (EBV). EBV latent membrane protein 1 (LMP1) interacts with TRAF proteins, linking LMP1-mediated B lymphocyte transformation to TNFR signaling. Three transcript variants encoding two different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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