Thermo Fisher Scientific Caspase 4 Precursor (Cleaved Gln81) Polyclonal Antibody
Rabbit polyclonal antibody recognizing cleaved Caspase 4 precursor (Gln81). Suitable for WB and IHC(P) applications. Detects endogenous activated Caspase4 fragment. Provided in liquid form, 1 mg/mL concentration, stored at −20 °C.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CASP4 (Accession P49662), corresponding to amino acid residues L73–P96 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | −20 °C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816725 |
Product Specific Information
Antibody detects endogenous levels of fragment of activated Caspase4 resulting from cleavage adjacent to Gln81.
Target Information
Caspases are cysteine proteases expressed as inactive precursors that mediate apoptosis by proteolysis of specific substrates. They cleave after aspartic acid residues and are divided into two classes:
- Initiator caspases (e.g., Caspase-8, Caspase-9) activated by receptor clustering
- Effector caspases (e.g., Caspase-3, Caspase-7) activated by mitochondrial permeability transition
Proapoptotic signals autocatalytically activate initiator caspases, which subsequently process effector caspases leading to cell collapse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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