Thermo Fisher Scientific AVPR1B Polyclonal Antibody

Thermo Fisher Scientific AVPR1B Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 2–7 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• Human, Gorilla, Gibbon: 100%
• Monkey, Marmoset: 89%
• Bovine: 84%

Target Information

Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell and continues to drive pharmacological research for new drug candidates.
Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.