Thermo Fisher Scientific AVPR1B Polyclonal Antibody

Thermo Fisher Scientific AVPR1B Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 2–10 µg/mL
Publications: –

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey (100%)
Marmoset, Elephant, Bat, Pig (88%)

Target Information

Vasopressin V1B receptor expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist.
All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs, leading to signaling via G-proteins and downstream effectors.
Ongoing studies have shown the vast series of reactions participating in the negative regulation of GPCRs, which has significant implications for cellular physiology and pharmacological research.
Two GPCR-targeted pharmaceuticals, Zyprexa (Eli Lilly) and Claritin (Schering-Plough), represent major successes in mental health and allergy treatment markets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.