Thermo Fisher Scientific AVPR1B Polyclonal Antibody
Rabbit polyclonal antibody against human AVPR1B, validated for IHC-P. Recognizes multiple mammalian species. Supplied as 1 mg/mL liquid, unconjugated, purified by antigen affinity chromatography. For research use only; not for diagnostic or resale purp...
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Applications
Immunohistochemistry (Paraffin) (IHC-P)
- Tested dilution: 4 µg/mL
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Bovine, Dog, Horse, Human, Pig, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from N-terminal extracellular domain of human AVPR1B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4 °C short term. For long term storage, store at −20 °C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550728 |
Product Specific Information
- Not recommended for ICC or WB applications.
- Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rat, Bovine, Dog, Bat, Elephant, Panda, Horse, Rabbit, Pig, Opossum (100%).
Target Information
Vasopressin V1B receptor (AVPR1B) expression has been documented in the pituitary, pituitary tumors, pheochromocytoma, breast cancer, and small-cell lung carcinomas.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices and existing in both active and inactive forms. Ligand binding induces conformational changes leading to G-protein signaling and downstream effects.
GPCR regulation mechanisms have significant physiological and pharmacological implications, contributing to the development of major GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering‑Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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