Thermo Fisher Scientific MET Monoclonal Antibody (OTI1E6), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

MET (c-MET) is a receptor-like tyrosine kinase associated with various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET is involved in embryonic development processes including gastrulation, muscle and neuron formation, angiogenesis, and kidney development. In adults, it contributes to wound healing, organ regeneration, and tissue remodeling. Dysregulation of MET has been linked to cancers such as gastric, renal, and breast cancer, making it a significant target in cancer therapeutics and diagnostics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.