Thermo Fisher Scientific IL-17F Monoclonal Antibody (SHLR17), eFluor 660, eBioscience
인간 IL-17F를 특이적으로 인식하는 SHLR17 단클론 항체로, eFluor 660 형광 표지되어 있습니다. Flow Cytometry에 최적화되어 있으며 Th17 세포 분석에 적합합니다. Alexa Fluor 647 대체 형광체를 사용하며 높은 감도와 안정성을 제공합니다.
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Thermo Fisher Scientific IL-17F Monoclonal Antibody (SHLR17), eFluor 660, eBioscience
Applications
- Flow Cytometry (Intracellular staining)
Tested Dilution: 5 µL (0.125 µg)/test
Applications Reported: Intracellular staining followed by flow cytometric analysis
Applications Tested: Pre-titrated and validated for Th17-polarized peripheral blood cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG1, kappa |
| Recommended Isotype Control | Rat IgG1 kappa Isotype Control (eBRG1), eFluor™ 660 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SHLR17 |
| Conjugate | eFluor™ 660 |
| Excitation / Emission Max | 651 / 668 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2574280 |
Additional Formats Available
- Brilliant UV 395
- Brilliant UV 563
- Brilliant UV 737
- Brilliant Violet 421
- Brilliant Violet 650
- eFluor 450
- Functional Grade
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Custom conjugation available upon request
Product Specific Information
The SHLR17 monoclonal antibody reacts with human interleukin (IL)-17F, a 34 kDa homodimeric cytokine belonging to the IL-17 family. IL-17F and IL-17A are produced primarily by Th17 cells and exhibit overlapping yet distinct functions. IL-17F binds to a heterodimeric receptor complex (IL-17RA/IL-17RC), inducing secretion of pro-inflammatory cytokines and chemokines, and promoting neutrophil recruitment.
This antibody is validated for intracellular staining followed by flow cytometric analysis. Recommended usage is 5 µL (0.125 µg) per test in a final volume of 100 µL. Cell number can range from 10⁵ to 10⁸ cells/test depending on experimental conditions.
eFluor® 660 serves as a replacement for Alexa Fluor® 647, excited by a red laser (633 nm) and emitting at 659 nm. Ensure instrument compatibility with this fluorochrome.
Excitation: 633–647 nm
Emission: 668 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
IL-17F (Interleukin 17F, CTLA-8) is a cytokine produced by activated T cells, mast cells, and basophils. It plays a key role in allergic airway inflammation and induces cytokines and chemokines in bronchial epithelial cells, endothelial cells, fibroblasts, and eosinophils. IL-17F may form homodimers or heterodimers with IL-17A, binding to IL-17R to recruit monocytes and neutrophils and stimulate production of TNF-α, IL-1β, IL-6, and IL-8. IL-17F is implicated in chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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