Thermo Fisher Scientific MLNR Polyclonal Antibody
인간 MLNR 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC(P) 검증 완료, 고순도 항원 친화 크로마토그래피 정제. PBS 버퍼에 0.1% sodium azide 포함, 4°C 단기/–20°C 장기 보관. 연구용 전용 제품.
- 카탈로그번호
- PA533938
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested at 1.1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human MLNR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551306 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla (100%), Monkey (95%), Gibbon, Marmoset, Bat (90%), Dog, Panda (85%), Bovine (80%).
Target Information
Motilin is a widely conserved 22 amino acid peptide hormone secreted from enterochromaffin cells of the gastrointestinal tract. Within the intestines, motilin potentiates intestinal motility by inducing contractions of the duodenum and through binding to surface receptors, designated GPR38 (G-protein coupled receptor 38).
These motilin receptors are predominantly expressed in stomach, thyroid, and bone marrow, and are related to other G-protein coupled receptors located in the pituitary and hypothalamus, which mediate signaling for growth hormone secretagogues.
The gene encoding GPR38 is alternately spliced at the carboxy terminus to generate two related proteins, GPR38-A and GPR38-B. Sequence comparisons indicate that GPR38-A contains seven transmembrane domains, while GPR38-B is predicted to contain five.
Consistent with other G-protein coupled receptors, GPR38 activates phospholipase C signal transduction pathways and induces intracellular calcium mobilization after binding of motilin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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