Thermo Fisher Scientific NLRP3 Monoclonal Antibody (nalpy3-b)

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000
• Publications: Refer to product references

Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: Assay-dependent
• Publications: Refer to product references

Immunoprecipitation (IP)

• Tested Dilution: 1:50
• Publications: Refer to product references

Product Specifications

Product Specific Information

MA1-25943 has a predicted molecular weight of approximately 118 kDa.

Target Information

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. The protein interacts with apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex.
This complex acts as an upstream activator of NF-kappaB signaling and plays a role in regulating inflammation, immune response, and apoptosis.
Mutations in this gene are associated with familial cold autoinflammatory syndrome and neonatal-onset multisystem inflammatory disease.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. Alternative 5′ UTR structures are suggested by available data, though insufficient evidence exists to determine biological validity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.