Thermo Fisher Scientific HLA-DR/DP/DQ Monoclonal Antibody (CR3/43)

Applications

Immunohistochemistry (IHC)

• Tested Dilution: -
• Publications: View 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:25–1:50
• Publications: View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: -
• Publications: View 1 publication

Product Specifications

Product Specific Information

• Recommended positive controls: Tonsil.

Target Information

MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
Three loci—DR, DQ, and DP—encode the major expressed products of the human class II region.
Human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells, playing a critical role in initiating the immune response.

HLA and MHC antibodies are essential in immunopeptidomics, aiding in the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem mass spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.