Thermo Fisher Scientific GNAS Monoclonal Antibody (OTI12D9), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Mutations in the GNAS gene are associated with:

• Pseudohypoparathyroidism type 1a and 1b
• Albright hereditary osteodystrophy
• Pseudopseudohypoparathyroidism
• McCune-Albright syndrome
• Progressive osseous heteroplasia
• Polyostotic fibrous dysplasia of bone
• Certain pituitary tumors

The GNAS gene exhibits complex imprinted expression with maternally, paternally, and biallelically expressed transcripts. It includes multiple alternatively spliced 5’ exons within differentially methylated regions. One alternate exon introduces a frameshift, producing an isoform structurally distinct from others. An antisense transcript may regulate imprinting in this region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.