Thermo Fisher Scientific Phospho-Rb (Ser608) Polyclonal Antibody
Rb 단백질의 Ser608 인산화를 검출하는 Rabbit Polyclonal 항체. Western blot, ELISA, IP에 사용 가능. 인간 시료에서 검증됨. 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| ELISA (ELISA) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from human retinoblastoma protein containing phosphorylated serine 608 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2533159 |
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription, and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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