Thermo Fisher Scientific KIDINS220 Polyclonal Antibody
KIDINS220 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 항원 친화 크로마토그래피 정제 및 안정적 액상 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within Human Kidins220 (aa 1,325–1,374) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C; avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2901107 |
Product Specific Information
Positive controls include SH-SY5Y cell lysates, N2A, PC-12, human pancreas tissue, human breast cancer tissue, mouse brain tissue, and SH-SY5Y cells.
Target Information
The KIDINS220 gene encodes a transmembrane protein predominantly expressed in the nervous system. It regulates neuronal survival, differentiation into axons and dendrites, and synaptic plasticity. The protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, acting as a scaffold for crosstalk between neurotrophin and other intracellular signaling pathways. Aberrant expression is linked to neuropsychiatric and neurodegenerative diseases, including Alzheimer’s disease. Mutations can cause a syndrome with spastic paraplegia, intellectual disability, nystagmus, and obesity. Alternative splicing generates multiple transcript variants.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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