Thermo Fisher Scientific CNR2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CNR2 (CB2) with high species identity. Validated for IHC (Paraffin) at 13–26 µg/mL. Supplied as 1 mg/mL liquid, unconjugated form. Recommended storage at 2–8°C short-term or -20°C long-term. For research use o...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 13–26 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human CNR2 / CB2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 1 month. For long-term storage, store at -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2550823 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey, Marmoset, Dog (100%); Mouse, Rat, Elephant, Panda (95%).
Target Information
Cannabinoids exert their physiological effects through two G protein-coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both receptors inhibit adenylyl cyclase and stimulate the mitogen-activated protein kinase (MAPK) pathway. CB1 receptors also modulate ion channels via direct G-protein interactions. Delta 9-tetrahydrocannabinol and related ligands likely exert psychoactive effects by inhibiting presynaptic N- and P/Q-type calcium channels. CB2 is thought to function primarily in the immune system, though it may also be present in the central nervous system, including the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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