Thermo Fisher Scientific Triadin Monoclonal Antibody (IIG12)

Applications

Product Specifications

Product Specific Information

MA3-931 detects triadin from mouse and rabbit skeletal muscle tissues. This antibody does not detect triadin from cardiac tissues.
MA3-931 has been successfully used in Western blot and immunohistochemistry procedures.
By Western blot, this antibody detects a single ~95 kDa band representing triadin in rabbit skeletal muscle extracts.
Immunofluorescence staining of triadin in rabbit skeletal muscle with MA3-931 results in its co-localization with ryanodine receptor, consistent with their association in triads.
The MA3-931 antigen is rabbit skeletal muscle triads.

Target Information

The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad.
At the triad, dihydropyridine receptors (DHPRs) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyRs), the calcium release channels, exist in the membrane of the terminal cisternae of the SR.
During slow phase depolarization of the T-tubule, triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPRs and RyRs.
Triadin co-localizes with both DHPR and RyR at the junctional face of the terminal cisternae.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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