Thermo Fisher Scientific S1P1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human S1P1 (EDG1) receptor for WB, IHC, and ICC/IF applications. High specificity and sensitivity, provided as 1 mg/mL liquid form. Suitable for research use only, stored at 4°C or -20°C.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human EDG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792217 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: HepG2, mouse liver.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins.
S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1, and MAP kinases. It plays an important role in cell migration via actin cytoskeleton reorganization and lamellipodia formation in response to sphingosine kinase SPHK1 activation.
S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, embryonic heart development, and cardiac morphogenesis.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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