Thermo Fisher Scientific MAEL Polyclonal Antibody
Rabbit polyclonal antibody against human MAEL protein. Validated for IHC (paraffin) with 1:200–1:500 dilution. Purified by antigen affinity chromatography, supplied in PBS with 40% glycerol. Suitable for research use in spermatogenesis and transposon r...
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MAEL. Recombinant protein control fragment (Product # RP-94271) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792213 |
Product Specific Information
Immunogen sequence:
PVFTPLRRPG MLVPKQNVSP PDMSALSLKG DQALLGGIFY FLNIFSHGEL PPHCEQRFLP CEIGCVKYSL QEGIMADFH
Target Information
The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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