Thermo Fisher Scientific ADAP Polyclonal Antibody
인간 ADAP(FYB1) 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P)에서 1:50~1:200 희석 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 40% 글리세롤에 보관. T세포 활성화 및 신호전달 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human FYB1. Recombinant protein control fragment (Product #RP-102114) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790090 |
Product Specific Information
Immunogen sequence:
RPFRVTGPNS SSGIQARKNL FNNQGNASPP AGPSNVPKFG SPKPPVAVKP SSEEKPDKEP KPPFLKPTGA GQRFGTPASL TTRDPEAKVG FLKPVGPKPI NLPKEDSKPT FPWPPGNKPS LHSVNQD
Target Information
The adhesion and degranulation adaptor protein (ADAP) was initially identified as a molecular adapter that couples T cell receptor (TCR) stimulation to the avidity of integrins governing T cell adhesion.
TCR stimulation promotes the formation of a multi-protein complex containing CARMA1, MALT1, and BCL-10, which through the association of ADAP, ultimately activates the NF-kappa-B family of transcription factors.
More recent experiments have shown that ADAP controls optimal T cell proliferation, cytokine production, and expression of the Bcl-2 family member Bcl-x(L), suggesting that ADAP regulates T cell activation by promoting antigen-dependent T cell–antigen presenting cell (APC) activation.
At least three isoforms of ADAP are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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