Thermo Fisher Scientific ARID1A Recombinant Rabbit Monoclonal Antibody (JJ09-01)
ARID1A 단백질을 인식하는 Thermo Fisher의 재조합 토끼 단일클론 항체로, IHC 및 ICC/IF 실험에 사용 가능. 높은 특이성과 민감도, 로트 간 일관성, 동물 유래 성분 없음. 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ09-01 |
| Immunogen | Recombinant protein within Human ARID1A aa 1,184–1,334 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809742 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
The ARID1A gene encodes a member of the SWI/SNF family, which includes proteins with helicase and ATPase activities that regulate transcription by modifying chromatin structure. The encoded protein is part of the ATP-dependent chromatin remodeling complex SNF/SWI, essential for transcriptional activation of genes repressed by chromatin.
Functional Domains:
- DNA-binding domain that binds AT-rich sequences recognized by the SNF/SWI complex
- C-terminal domain that stimulates glucocorticoid receptor-dependent transcriptional activation
The ARID1A protein confers specificity to the SNF/SWI complex and may recruit it to target sites via protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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