Thermo Fisher Scientific IL-17A Monoclonal Antibody (4H1524.1), Biotin
Human IL-17A 단백질에 특이적인 mouse monoclonal antibody로, Biotin conjugate 형태 제공. Western blot, Flow cytometry, ELISA 등 다양한 응용 가능. 고순도 Protein G 정제, 안정적 보관 및 장기 저장 가능.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | |
| Flow Cytometry (Flow) | Assay-dependent | |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H1524.1 |
| Immunogen | Anti-IL-17A (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with mature full-length recombinant human IL-17A produced in E. coli followed by hybridoma development. |
| Conjugate | Biotin |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 10 mg/mL BSA, 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
Store vial at 4°C prior to restoration. Restore with 0.1 mL of deionized water (or equivalent).
For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for human IL-17A protein. A BLAST analysis suggests cross-reactivity with IL-17A from human sources based on 100% homology with the immunizing sequence. Cross-reactivity with IL-17A from other sources has not been determined.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer consisting of 136 amino acids and is a member of the IL-17 family (IL-17A–IL-17F).
It signals through the IL-17 receptor (IL-17R/CDw217) and enhances expression of ICAM-1 in human fibroblasts.
Human IL-17A stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2, and supports proliferation of CD34+ hematopoietic progenitors, inducing maturation into neutrophils.
IL-17A regulates NF-κB and MAPK activities, stimulates IL-6 and COX-2 (PTGS2) expression, and enhances nitric oxide production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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