Thermo Fisher Scientific IL-6 Monoclonal Antibody (6B4 IGH 54), eBioscience
마우스 IL-6를 특이적으로 인식하는 단클론 항체로, ELISA 및 기능적 중화 실험에 적합합니다. 50 pg/mL IL-6 활성을 95% 이상 억제하며, 고순도(>95%)로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| ELISA | Assay-Dependent | View 1 publication |
| Neutralization | - | View 2 publications |
| Functional Assay | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6B4 IGH 54 |
| Immunogen | Recombinant Mouse IL-6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10597433 |
Product Specific Information
Clone 6B4 IGH 54 can neutralize the activity of 50 pg/mL recombinant mouse IL-6 by >95% in a functional assay.
Applications Tested: ELISA, Functional Studies (Blocking).
Purity: >95%.
Target Information
IL-6 encodes a cytokine involved in inflammation and B cell maturation. This protein acts as an endogenous pyrogen that induces fever in autoimmune or infectious conditions.
It is mainly expressed at sites of acute and chronic inflammation and secreted into serum, initiating inflammatory transcriptional responses through the interleukin-6 receptor alpha.
IL-6 function is implicated in various inflammation-associated diseases, including diabetes mellitus susceptibility and systemic juvenile rheumatoid arthritis.
Elevated IL-6 levels are also observed in viral infections such as COVID-19 (caused by SARS-CoV-2).
Diseases associated with IL-6 include Kaposi Sarcoma and Systemic Juvenile Rheumatoid Arthritis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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