Thermo Fisher Scientific IL-6 Monoclonal Antibody (6B4 IGH 54), eBioscience

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-Dependent

View 1 publication 1 publication

Neutralization (Neu)

-

View 2 publications 2 publications

Functional Assay (Functional)

Assay-Dependent

-

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Rat / IgG1

Class

Monoclonal

Type

Antibody

Clone

6B4 IGH 54

Immunogen

Rec. Mouse IL-6

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_10597433

Product Specific Information

Description: Clone 6B4 IGH 54 can be used to neutralise the activity of 50pg/mL of recombinant mouse IL-6 by >95% in a functional assay.

Applications Tested: ELISA, Functional Studies (Blocking).

Purity: >95%.

Target Information

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.