Thermo Fisher Scientific RhoA Polyclonal Antibody
RhoA 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA에 적합합니다. Human과 Mouse에 반응하며 액상 형태로 제공됩니다. 세포막 및 세포골격 관련 연구에 활용 가능하며 고순도 친화 크로마토그래피로 정제되었습니다.
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Thermo Fisher Scientific RhoA Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
| Miscellaneous PubMed | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 94–193 of human RhoA (NP_001655.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.24 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804123 |
Product Specific Information
Immunogen sequence:
NIPEKWTPEV KHFCPNVPII LVGNKKDLRN DEHTRRELAK MKQEPVKPEE GRDMANRIGA FGYMECSAKT KDGVREVFEM ATRAALQARR GKKKSGCLVL
Positive Samples:
Mouse brain, Mouse spleen, Rat lung
Cellular Location:
Cell membrane, Cell projection, Cleavage furrow, Cytoplasm, Cytoplasmic side, Lipid-anchor, Midbody, Cell cortex, Cytoskeleton, Lamellipodium
Target Information
RhoA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. It is involved in a microtubule-dependent signal required for myosin contractile ring formation during cytokinesis and plays an essential role in cleavage furrow formation. RhoA is required for apical junction formation of keratinocyte cell-cell adhesion and serves as a target for the yopT cysteine peptidase from Yersinia pestis and Yersinia pseudotuberculosis. It stimulates PKN2 kinase activity and may activate PLCE1. It is activated by ARHGEF2, promoting GDP-GTP exchange, and is essential for SPATA13-mediated regulation of cell migration and adhesion assembly/disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway is critical for ERBB2-dependent microtubule stabilization at the cell cortex, controlling APC and CLASP2 localization via GSK3B regulation, enabling MACF1-mediated microtubule capture and stabilization.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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