Thermo Fisher Scientific POLR1C Polyclonal Antibody
Thermo Fisher Scientific의 POLR1C Polyclonal Antibody는 인간 POLR1C 단백질을 인식하는 토끼 IgG 항체로, WB 및 ELISA에 적합합니다. 핵 위치 단백질 검출에 사용되며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing sequence corresponding to amino acids 1–200 of human POLR1C (NP_976035.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.98 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804122 |
Product Specific Information
- Immunogen sequence:
MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR LFEYRNQGDE EGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHKVYT RHMTWIPLGN QADLFPEGTI RPVHDDILIA - Positive Samples: K-562, 293T, MCF7
- Cellular Location: Nucleus
Target Information
RNA polymerases transcribe nuclear genes for ribosomal RNA, thus representing ribosomal biogenesis.
RNA polymerase I (Pol I) is located in the nucleolus and transcribes class I genes, which code for large ribosomal RNA.
Different subunits of the Pol I transcription machinery are targets of various physiological stimuli, suggesting that multiple signaling pathways are involved in Pol I transcription.
RPA16, RPA40, and RPA135 are subunits of Pol I that associate early in RNA Pol I assembly. RPA40 is essential for the function and integrity of the complex and is also a critical subunit of RNA polymerase III (Pol III).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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