Thermo Fisher Scientific CD98 Chimeric Recombinant Rabbit Monoclonal Antibody (HBJ127)

Applications

Product Specifications

Immunogen

HBJ127 was obtained from hybridomas generated by the fusion of mouse myeloma cells and spleen cells from mice immunized with T24 human bladder cancer cells.

Antigen Information:

• Target Family: CD98
• UniProt ID: P08195-1
• Species: Human (NCBI Node ID: 9606)
• Antigen Range: 1–630
• Antigen Length: 630

Product Specific Information

Specificity: HBJ127 binds to the CD98 heavy chain at an epitope consisting of residues AFS (aa 442–444). The antibody has not been shown to cross-react with other species.
CD98 is expressed at high levels on monocytes and at very low levels on peripheral blood T and B lymphocytes, splenocytes, NK cells, and granulocytes.

Target Information

CD98 (4F2) is a type II transmembrane glycoprotein that serves as the heavy chain of heterodimeric amino acid transporters (HATs). CD98 is linked to various light chains by disulfide bonds, enabling cell surface expression and basolateral localization in polarized epithelial cells. It also interacts with β1 integrins, enhancing their ligand affinity.
Beyond amino acid transport, CD98 plays roles in cell fusion, activation, differentiation, growth, and apoptosis regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.