Thermo Fisher Scientific COMT Polyclonal Antibody
Human COMT 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 연구용에 적합. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼와 sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from N-terminus of human COMT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550173 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla (100%)
Gibbon, Monkey (95%)
Marmoset (89%)
Hamster (84%)
Target Information
Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including dopamine, epinephrine, and norepinephrine.
This O-methylation is a major degradative pathway of catecholamine neurotransmitters.
COMT also plays an important role in the metabolism of catechol drugs used for hypertension, asthma, and Parkinson’s disease.
COMT exists in two forms: soluble (S-COMT) and membrane-bound (MB-COMT), differing in their N-termini.
Multiple transcript variants are generated via alternative translation initiation sites and promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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