Thermo Fisher Scientific ADAM23 Polyclonal Antibody
ADAM23 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 검증됨. 인간 및 생쥐 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 세포 부착 및 신호전달 연구에 적합. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human ADAM23 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719329 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
ADAMs (a disintegrin and metalloproteinase domain), also known as MDCs (metalloproteinase, disintegrin, and cysteine-rich domain) or cellular disintegrins, are a family of proteins expressed in numerous tissues. They participate in proteolysis, adhesion, fusion, and intracellular signaling.
ADAM23 is a membrane-anchored protein expressed exclusively in fetal and adult brain and may function as an integrin ligand in neural cells. The disintegrin-like domain of ADAM23 promotes adhesion of neuroblastoma and astrocytoma cells through interaction with αvβ3 integrin.
Unlike other metalloproteinases, ADAM23 lacks the three characteristic histidine residues and glutamic acid residue in its metalloproteinase-like domain, suggesting it may function primarily in cell adhesion rather than protease-mediated events. Evidence also suggests ADAM23 may act as a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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