Thermo Fisher Scientific IREB2 Polyclonal Antibody
IREB2 단백질을 인식하는 산양 유래 폴리클로날 항체로, Western blot과 IHC(P)에서 검증됨. 인간, 생쥐, 랫트에 반응하며, 합성 펩타이드(aa 489-503)를 면역원으로 사용. 0.5 mg/mL 농도의 액상 형태로, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–6 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (SIHYEGSEYKLSHGS) corresponding to the internal amino acids of IREB2 (aa 489–503) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_11001588 |
Product Specific Information
- This antibody is predicted to react with mouse and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
Iron regulatory protein 2 (IRP2) is a central post-transcriptional regulator of cellular and systemic iron metabolism. It is a cytosolic RNA-binding protein that binds to stem-loop structures and is regulated by iron-mediated proteolysis.
Hypoxia plays a key role in normal tissue physiology and in several pathophysiological conditions, including cardiovascular diseases and tumor growth. Because iron and oxygen are closely related, IRP2 also functions during hypoxia (low oxygen).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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