Thermo Fisher Scientific JAM-A (CD321) Polyclonal Antibody

Applications

• Western Blot (WB): 0.3–2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with canine, mouse, porcine, and rat based on sequence homology.
Tested in Peptide ELISA: antibody detection limit dilution 2,000.

Target Information

CD321 (F11R, JAM-1, JAM-A) is a cell-surface adhesion molecule belonging to the Ig superfamily of receptors. It is a 32–41 kD glycoprotein with two extracellular Ig-like domains, a transmembrane region, and a short cytosolic tail.
The protein forms homodimers at the membrane and associates with other membrane proteins, including integrins.
CD321 is expressed on leukocytes, platelets, erythrocytes, stem cells, epithelial and endothelial cells, and mediates cell-cell contact.
It is located near epithelial tight junction components such as ZO-1 and occludin and plays roles in maintaining epithelial and endothelial barriers, hematopoiesis, angiogenesis, and tumor proliferation, invasion, and metastasis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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