Thermo Fisher Scientific GUCY1B3 Polyclonal Antibody
GUCY1B3 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot, IHC(P), IP에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 용액 형태로 제공. 인체, 마우스, 랫트 시료에 반응.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide to the N-terminus of Human GUCY1B3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718897 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as a receptor for nitric oxide, and a membrane-bound receptor form (GC), which serves as a peptide hormone receptor.
The GC-C protein consists of:
- An extracellular domain
- A single transmembrane domain
- A cytoplasmic region with kinase-like and catalytic domains
It is expressed as two glycosylated forms:
- 130 kDa precursor (endoplasmic reticulum)
- 145 kDa mature form (plasma membrane)
Ligand binding to the extracellular domain of GC-C promotes cGMP accumulation. GC-C acts as the receptor for heat-stable enterotoxins from pathogenic E. coli, causing secretory diarrhea, and also binds guanylin and uroguanylin peptides that modulate renal function.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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