Thermo Fisher Scientific APP Polyclonal Antibody
APP 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 마우스, 랫트 반응성 확인. WB 및 IHC에 사용 가능하며, 합성 펩타이드(aa 400-450)를 면역원으로 제작. 장기 보관 시 -20°C 권장, 연구용으로만 사용.
- 카탈로그번호
- OSA00050G-500UG
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific APP Polyclonal Antibody
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 400–450 of human APP conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: APP.
Target Information
Amyloid Precursor Protein (APP), also known as Amyloid beta precursor protein, functions as a cell surface kinesin I membrane receptor mediating the axonal transport of beta-secretase and presenilin 1.
APP is important for neurite growth, neuronal adhesion, and axonogenesis.
It is a 100–140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing.
Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, the primary component of senile plaques—one of the major histopathologic features of Alzheimer’s disease.
Abnormal regulation and processing of APP also play roles in Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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