Thermo Fisher Scientific ZP2 Polyclonal Antibody
Thermo Fisher Scientific ZP2 Polyclonal Antibody는 인간, 마우스, 랫트에서 반응하는 Rabbit IgG 폴리클로날 항체로, Western blot, ICC/IF, ELISA에 적합합니다. 고순도 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관됩니다. 난자 주변막(Zona Pellucida) 단백질 연구용으로 최적화되었습니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 651–745 of human ZP2 (NP_0034511) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.87 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804322 |
Product Specific Information
Immunogen sequence:
KMTVSLPGPI LLLSDDSSFR GVGSSDLKAS GSSGEKSRSE TGEEVGSRGA MDTKGHKTAG DVGSKAVAAV AAFAGVVATL GFIYYLYEKR TVSNH
Positive Samples: SH-SY5Y, HL-60, SW620, Mouse liver, Rat ovary
Cellular Location: Cell membrane, Single-pass type I membrane protein, extracellular matrix, extracellular space
Target Information
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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