Thermo Fisher Scientific LAIR1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 22-163 of human LAIR1 (NP_0022782) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LAIR1 (CD305),uniProtId:Q6GTX8-1,ncbiNodeId:9606,antigenRange:22-163,antigenLength:287,antigenImageFileName:PA5-87648_LAIR1_CD305_Q6GTX8-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87648_LAIR1_CD305_Q6GTX8-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.11 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804318

Product Specific Information

Positive Samples: B-cell, Jurkat, HL-60, Raji, Mouse brain, Mouse liver, Mouse lung, Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane protein

Immunogen sequence: QEEDLPRPSI SAEPGTVIPL GSHVTFVCRG PVGVQTFRLE RDSRSTYNDT EDVSQASPSE SEARFRIDSV REGNAGLYRC IYYKPPKWSE QSDYLELLVK ESSGGPDSPD TEPGSSAGPT QRPSDNSHNE HAPASQGLKA EH

Target Information

LAIR1 (CD305) functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.