Thermo Fisher Scientific CYP4F2 Polyclonal Antibody
Thermo Fisher Scientific의 CYP4F2 Polyclonal Antibody는 인간 CYP4F2 단백질을 인식하는 토끼 유래 IgG 항체로, Western blot 및 ELISA에 적합합니다. 액상 형태로 제공되며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로 간 및 신장 조직의 CYP4F2 발현 분석에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 40–120 of human CYP4F2 (NP_0010733) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.14 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804324 |
Product Specific Information
- Immunogen sequence: AFYDNCRRLR CFPQPPRRNW FWGHQGMVNP TEEGMRVLTQ LVATYPQGFK VWMGPISPLL SLCHPDIIRS VINASAAIAP K
- Positive Samples: LO2, HepG2, 293T
- Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein
Target Information
CYP4F isoforms are involved in the oxidation of important cellular mediators, such as leukotriene B4 (LTB4) and prostaglandins.
CYP4F2 catalyzes omega-hydroxylation of LTB4 to a less potent proinflammatory eicosanoid, 20-OH-LTB4, as well as arachidonic acid.
CYP4F2 is expressed in liver and kidney. Its expression is repressed by peroxisomal proliferators and induced by retinoic acid.
X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder characterized by elevated levels of very long-chain fatty acids (VLCFA).
CYP4F2 participates in the omega-hydroxylation of VLCFAs, which may provide an alternative mode of treatment for X-ALD patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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