Thermo Fisher Scientific Cdc34 Polyclonal Antibody
CDC34 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot에 최적화되어 있습니다. 인간, 마우스, 랫트 시료에 반응하며, 고순도의 Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5118890
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Cdc34 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CDC34 (Accession P49427), corresponding to amino acid residues F46–I96 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903390 |
Product Specific Information
Antibody detects endogenous levels of total CDC34.
Target Information
CDC34 accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, it catalyzes Lys-48–linked polyubiquitination. It cooperates with the E2 UBCH5C and the SCF (FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA, leading to its proteasomal degradation. CDC34 also participates in ubiquitin chain elongation, working with UBE2D3 to build NFKBIA-linked ubiquitin chains. Additionally, it cooperates with the SCF (SKP2) E3 ligase complex to regulate cell proliferation via ubiquitination and degradation of MYBL2 and KIP1. CDC34 is involved in degradation of CREM isoform ICERIIgamma and ATF15, affecting cAMP-induced transcription, and in G2/M phase regulation through WEE1 kinase degradation. It also targets beta-catenin and interacts dynamically with proteasomes under the influence of human herpes virus 1 protein ICP0.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.