Thermo Fisher Scientific Cullin 4B Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal Antibody로, CUL4B 단백질을 검출. Western blot에 1:1,000~1:3,000 희석 비율로 사용. Affinity chromatography로 정제된 액상 형태이며, PBS/glycerol buffer에 보존. DNA 손상 및 mTOR 경로 연구에 적합.
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Applications
- Western Blot (WB): 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human CUL4B (Accession Q13620), amino acids F24–E74 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903382 |
Product Specific Information
Antibody detects endogenous levels of total CUL4B.
Target Information
CUL4B is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes, mediating ubiquitination and proteasomal degradation of target proteins. It acts as a scaffold protein, positioning substrates and ubiquitin-conjugating enzymes.
Involved in polyubiquitination of CDT1, histones H2A, H3, and H4 following radiation-induced DNA damage. Targeted to UV-damaged chromatin by DDB2, playing a role in DNA repair and replication.
Required for cyclin E ubiquitination and normal G1 cell cycle progression. Regulates the mTOR pathway controlling cell growth and metabolism, with CUL4B-dependent regulation of mTORC1 requiring 26S proteasome and MLST8 interaction.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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